• Citer

Synthesis of Nitrogen Heterocycles from Ynamides and Enamides

par Zhang, Chunyang
Président du jury Moucheron, Cécile
Promoteur Evano, Gwilherm ;Blanchard, Nicolas
Publication Non publié, 2020-04-01

Thèse de doctorat

• Accès en ligne
• Détails
• Contenu
• Statistiques

Résumé :

This thesis has mainly focused on the development of new methods towards the synthesis of highly valuable nitrogen-containing heterocycles starting from either ynamides or their relative enamides, in which a radical-mediated intramolecular cyclization of ynamides was eventually developed for the synthesis of a series of N-heterocycles. Moreover, using both N-cyclopropyl and N-cyclobutyl enamides as substrates, two palladium catalyzed intramolecular cyclizations were accomplished to give the corresponding 1,4-dihydropyridines and cyclobutyl-fused pyrrolidines, respectively. The latter not only possesses theoretical significance, but also provide new routes to a variety of nitrogen heterocyclic compounds that are valuable building blocks in medicinal chemistry.