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The triumvirate of beta-cell regeneration: solutions and bottlenecks to curing diabetes

par Singh, Sumeet Pal ;Ninov, Nikolay
Référence The International journal of developmental biology, 62, 6-7-8, page (453-464)
Publication Publié, 2018-01-01

Article révisé par les pairs

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Résumé :

On 11 January 1922 insulin injection was used for the first time in the treatment of diabetes. Even today, daily insulin injections are the life-saving treatment for patients with Type 1 diabetes and advanced Type 2 diabetes. However, insulin injections often fail to achieve full glucose control, which in the long-term leads to multiple complications and mortality. Beta-cells, the natural producers and secretors of insulin, remain the gold-standard in regulating blood glucose levels. In this review, we focus on three strategies aiming at counteracting beta-cell loss in order to gain insulin independence: replacement, replication and protection. The three approaches, together termed as the triumvirate of beta-cell regeneration, may constitute the basis for a future cure for diabetes.