Résumé : The Infrared Atmospheric Sounding Instrument (IASI) on the Metop satellite suite has just achieved 10 years of continuous operation. The instrument stability and the consistency between the different instruments on the successive Metop (A, B and C) is remarkable and offer the potential to investigate the trends in the concentration of various species better than with any other previous or current hyperspectral IR sounder. The low noise of IASI radiances is also such that even weakly absorbing species can be identified, on single or at least on averaged spectra. In this work we exploit the first decadal record of IASI measurements to (1) detect and monitor halogenated compounds regulated by the Montreal protocol (CFCs) or used as substitutes (HCFCs, HFCs), as well as fluorinated compounds (CF4, SF6) and potentially short lived chlorine species, for which substantial emissions are suspected (2) give a first assessment of the trend evolution of these species over the 2008-2018 period covered by IASI on Metop-A. This is done by targeting various geographical areas on the globe and looking at remote ocean and continental source regions separately. The trend evolution in the different compounds, either negative or positive, is validated against that from ground-based measurement network. We will conclude by assessing the usefulness of IASI and follow-on mission to contribute to global measurements of ozone depleting substances.