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CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies

par Feng, William W.W.;Wilkins, Owen;Bang, Scott;Ung, Matthew;Li, Jiaqi;An, Jennifer;del Genio, Carmen;Canfield, Kaleigh;DiRenzo, James;Wells, Wendy;Gaur, Arti;Robey, Brooks R.B.;Guo, Jessie Yanxiang;Powles, Ryan Lee;Sotiriou, Christos ;Pusztai, Lajos;Febbraio, Maria;Cheng, Chao;Kinlaw, William W.B.;Kurokawa, Manabu
Référence Cell reports, 29, 11, page (3405-3420.e5)
Publication Publié, 2019-12

Article révisé par les pairs

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Résumé :

The functional significance of lipid metabolism in cancer cells is not fully understood. Feng et al. show that the fatty acid transporter CD36 is essential for survival of breast cancer cells during anti-HER2 therapy, highlighting the role of lipid metabolism in acquired resistance to targeted therapy.