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Primaquine liposomes in the chemotherapy of experimental murine malaria

par Pirson, Philippe;Steiger, Rolf R.F.;Trouet, André ;Gillet, Jean;Herman, F.
Référence Annals of tropical medicine and parasitology, 74, 4, page (383-391)
Publication Publié, 1980

Article révisé par les pairs

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Résumé :

Due to a significant reduction of toxicity, 100% curative (causal prophylactic) doses of primaquine diphosphate entrapped in liposomes (60 and 70 mg/kg body weight) can be administered in a single intravenous injection to treat sporozoite-induced Plasmodium bergheiinfections of mice.Although drug activity is not enhanced as compared to free drug, a simplified experimental therapy scheme could be developed, which may facilitate comparative pharmacokinetic studies of various drug delivery systems. © 1980 Liverpool School of Tropical Medicine.