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Contribution of post-transcriptional gene regulation during cellular adaptation to stress: Involvement of TTP in Drosophila cells during variation of oxygen concentration and in the homeostasis of intestinal immune cells in mice

par De Toeuf, Bérengère
Président du jury Vanhamme, Luc
Promoteur Gueydan, Cyril
Co-Promoteur Oldenhove, Guillaume
Publication Non publié, 2019-11-22

Thèse de doctorat

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Résumé :

TTP/Tis11 family of proteins are a major family of AU-rich elements binding proteins (ARE-BPs) that have been shown to play a particularly important role in the control of inflammation and in cancer, mostly by inducing the rapid decay of their target ARE containing mRNAs. TTP/Tis11 proteins levels are tightly controlled and highly affected by environmental cues as well as cell type. In this work, we studied the role of TTP/Tis11 proteins in two different settings where their protein levels might be strongly affected. dTis11 protein was strongly affected by oxygen concentration variation in Drosophila S2 cells and was involved in the control of the metabolic adaptation of S2 cells to those changes. In the other setting, TTP was shown to be involved in the homeostasis of intestinal Treg cells in mice through the control of the mRNA encoding RALDH2, an enzyme of the vitamin A metabolism.