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Host and microbial factors in kidney transplant recipients with Escherichia coli acute pyelonephritis or asymptomatic bacteriuria: a prospective study using whole-genome sequencing.

par Coussement, Julien ;Argudín, María Ángeles M.A.;Heinrichs, Amélie ;Racapé, Judith ;De Mendonça, Ricardo ;Nienhaus, Louise ;Le Moine, Alain ;Roisin, Sandrine ;Dodemont, Magali ;Jacobs, Frédérique ;Abramowicz, Daniel ;Johnston, Brian BD;Johnson, James R;Denis, Olivier
Référence Nephrology, dialysis, transplantation, 34, 5, page (878-885)
Publication Publié, 2019-05-01

Article révisé par les pairs

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Résumé :

Urinary tract infection is the most common infection among kidney transplant recipients (KTRs). Many transplant physicians fear that host compromise will allow low-virulence strains to cause pyelonephritis in KTRs, so they often treat asymptomatic bacteriuria with antibiotics. Identification of the host/microbe factors that determine the clinical presentation (i.e. pyelonephritis versus asymptomatic bacteriuria) once an Escherichia coli strain enters a KTRs bladder could inform management decisions.