par Fossati, Pierre;L'Hermite, Marc 
;Derrien, G.;Golstein Golaire, Jacqueline ;Vanhaelst, Luc ;Robyn, Claude ;Linquette, M.
Référence Annales d'Endocrinologie, 36, 3, page (145-151)
Publication Publié, 1975
;Derrien, G.;Golstein Golaire, Jacqueline ;Vanhaelst, Luc ;Robyn, Claude ;Linquette, M.Référence Annales d'Endocrinologie, 36, 3, page (145-151)
Publication Publié, 1975
Article révisé par les pairs
| Résumé : | PRL and TSH were measured by radioimmunoassay in 14 persons with myxedema aged 16 to 65 yr. 3 of them had galactorrhea. In 13 patients the circadian rhythm of PRL was studied, and in 8 patients PRL was measured after TRH administration. All the patients had a high value of serum TSH, with a mean value ± SEM of 29.4 (24.3 - 35.6) mU/ml. Values of serum PRL were comprised in normal ranges with a mean value ± SEM of 126 (196 - 238) mU/ml. The circadian rhythm of PRL is not altered, since mean values of serum PRL are more elevated at 4 am than 8 am with highly statistical significance. After THR administration the PRL response is normal or exaggerated. The results suggest that TSH release is quite independent of PRL release in hypothyroidism. Three hypothyroid patients with galactorrhea had a normal serum PRL value. This suggests that galactorrhea is a consequence of an altered activity of the 'lactogenic complex' comprising especially TSH and thyroid hormones. |
