Brain cell death is reduced with cooling by 3.5°C to 5°C but increased with cooling by 8.5°C in a piglet asphyxia model.

Alonso-Alconada, Daniel; Broad, Kevin D; Bainbridge, Alan; Chandrasekaran, Manigandan; Faulkner, Stuart; Kerenyi, Áron; Hassell, Jane; Rocha-Ferreira, Eridan; Hristova, Mariya; Fleiss, Bobbi; Bennett, Kate; Kelen, Dorottya; Cady, Ernest; Gressens, Pierre; Golay, Xavier; Robertson, Nicola NJ

doi:doi/10.1161/STROKEAHA.114.007330

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Brain cell death is reduced with cooling by 3.5°C to 5°C but increased with cooling by 8.5°C in a piglet asphyxia model.

par Alonso-Alconada, Daniel ;Broad, Kevin D ;Bainbridge, Alan ;Chandrasekaran, Manigandan ;Faulkner, Stuart ;Kerenyi, Áron ;Hassell, Jane ;Rocha-Ferreira, Eridan ;Hristova, Mariya ;Fleiss, Bobbi ;Bennett, Kate ;Kelen, Dorottya

;Cady, Ernest ;Gressens, Pierre ;Golay, Xavier ;Robertson, Nicola NJ
Référence Stroke, 46, 1, page (275-278)
Publication Publié, 2015-01

Article révisé par les pairs

Résumé :

In infants with moderate to severe neonatal encephalopathy, whole-body cooling at 33°C to 34°C for 72 hours is standard care with a number needed to treat to prevent a adverse outcome of 6 to 7. The precise brain temperature providing optimal neuroprotection is unknown.

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