par Valkenier, Hennie
Référence XI Young Inverstigator Workschop (11-13 July 2019: Vienna, Austria)
Publication Non publié, 2019-07-11
Communication à un colloque
Résumé : Synthetic receptors can be used to carry ions across membranes. Such carriers extract the anion from the aqueous phase, move it across the apolar interior of the lipid bilayer, to then release it on the other side of the membrane. They have potential for the treatment of diseases linked to deficient anion transport, such as cystic fibrosis [1]. Macrocyclic receptors are preorganised in a particular way, often leading to remarkable selectivities in binding and hence unique behaviour in anion transport. A first example are bambus[6]uril macrocycles, which are highly efficient in exchanging Cl− and HCO3− [2], while related biotin[6]urils do not show any transport of HCO3− [3]. Another example are calix[6]arene tris(thio)ureas, of which the cavity can be exploited to transport organic ion pairs [4].