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PERSEPHONE — implications for clinical practice in 2019

par Pondé, Noam;de Azambuja, Evandro
Référence Nature reviews. Clinical oncology
Publication Publié, 2019

Article révisé par les pairs

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Résumé :

Five randomized trials have been conducted to prove that shorter duration of trastuzumab treatment (9 weeks or 6 months) can replace the standard duration (1 year). The results of PERSEPHONE, the most recent trial, suggest that the efficacy of a 6-month treatment is non-inferior to that of 1 year, although not for all patients. We discuss these results in the context of current treatment standards.