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Skin lesion imaging with line-field confocal optical coherence tomography

par Cazalas, Maxime;Levecq, Olivier;Azimani, Hicham;Siret, David;Barut, Anaiss;Suppa, Mariano ;Del Marmol, Véronique ;Malvehy, Josep;Cinotti, Elisa;Rubegni, Pietro;Perrot, Jean Luc Uc J.L.;Dubois, Arnaud
Référence Progress in biomedical optics and imaging, 10851, 108510M
Publication Publié, 2019-12-01

Article révisé par les pairs

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Résumé :

An improved optical coherence tomography (OCT) technique called line-field confocal OCT (LC-OCT) has been developed for high-resolution skin imaging. Combining the principles of time-domain OCT and confocal microscopy with line illumination and detection, LC-OCT acquires multiple A-scans in parallel with dynamic focusing. With a quasi isotropic resolution of ∼1 μm, the LC-OCT images reveal a comprehensive structural mapping of skin, in vivo, at the cellular level down to a depth of ∼500 μm. LC-OCT images of various skin lesions, including carcinomas and melanomas, are found to well correlate with histopathological images. LC-OCT could significantly improve clinical diagnostic accuracy, while reducing the number of biopsies of benign lesions.