par Telerman Toppet, Nicole 
;Coërs, Christian
Référence Journal of the neurological sciences, 25, 4, page (449-461)
Publication Publié, 1975
;Coërs, Christian Référence Journal of the neurological sciences, 25, 4, page (449-461)
Publication Publié, 1975
Article révisé par les pairs
| Résumé : | The histochemical changes in Type II atrophy were compared to the motor innervation pattern in biopsy specimens obtained from patients with or without clinical evidence of denervation.Several quantitative data of the muscle fibres were analyzed, namely AI and AII factors, Type I/II ratio, the proportion of Type III fibres and of small fibres of Type III (S F III), strongly reactive to both NADH diaphorase and ATP ase. The collateral ramification of motor axons was estimated by the measurement of the terminal innervation ratio (TIR).No significant histochemical changes were found in relation to clinical eviden ce of denervation. The only obvious morphological difference was an increased TIR in disorders of the lower motor neurone or peripheral nerves.The analysis of muscle fibre changes in relation to TIR led to the following conclusions:1.(1) A very marked volumetric and numerical reduction of Type II fibres (high value of AII factor and Type I/II ratio) is suggestive of a neural defect, but there is no statistical evidence of this correlation.2.(2) The only histochemical evidence that denervation is taking place in Type II atrophy is the presence of S F III. The angular shape of these fibres is not relevant in their identification.3.(3) The occurrence of Type II atrophy without an increased TIR nor S F III indicates that this change may occur without any neurogenic participation. |
