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Total Synthesis of Conulothiazole A

par Nitelet, Antoine ;Gerard, Phideline ;Bouche, Jimmy ;Evano, Gwilherm
Référence Organic letters, 21, page (4318-4321)
Publication Publié, 2019-10-01

Article révisé par les pairs

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Résumé :

An efficient total synthesis of the chlorinated thiazole-containing natural product conulothiazole A is reported. Key features of this synthesis include a novel rhodium-catalyzed enantioselective hydrogenation of a 2-enamido-thiazole and a vinylic Finkelstein reaction that could be implemented at all stages of the synthesis to install the chlorinated alkene.