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Inflammatory parameters associated with systemic reactogenicity following vaccination with adjuvanted hepatitis B vaccines in humans.

par Burny, Wivine ;Marchant, Arnaud ;Hervé, Caroline;Callegaro, Andrea;Caubet, Magalie;Fissette, Laurence;Gheyle, Lien;Legrand, Catherine;Ndour, Cheikh;Tavares Da Silva, Fernanda;van der Most, Robbert;Willems, Fabienne ;Didierlaurent, Arnaud M;Yarzabal, Juan;ECR-008 study group,
Référence Vaccine
Publication Publié, 2019-03

Article révisé par les pairs

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Résumé :

Adjuvants like AS01B increase the immunogenicity of vaccines and generally cause increased transient reactogenicity compared with Alum. A phase II randomized trial was conducted to characterize the response to AS01B and Alum adjuvanted vaccines. A post-hoc analysis was performed to examine the associations between reactogenicity and innate immune parameters.