par Dold, Markus;Bartova, Lucie;Fugger, G.;Kautzky, Alexander;Souery, Daniel ;Mendlewicz, Julien ;Papadimitriou, George;Dikeos, Dimitris;Ferentinos, Panagiotis;Porcelli, Stefano;Serretti, Alessandro;Zohar, Joseph;Montgomery, Stuart;Kasper, Siegfried S.F.
Référence International journal of neuropsychopharmacology, 21, 6, page (539-549)
Publication Publié, 2018
Référence International journal of neuropsychopharmacology, 21, 6, page (539-549)
Publication Publié, 2018
Article révisé par les pairs
Résumé : | Background: This European multicenter study aimed to elucidate suicidality in major depressive disorder. Previous surveys suggest a prevalence of suicidality in major depressive disorder of ≥50%, but little is known about the association of different degrees of suicidality with socio-demographic, psychosocial, and clinical characteristics. Methods: We stratified 1410 major depressive disorder patients into 3 categories of suicidality based on the Hamilton Rating Scale for Depression item 3 (suicidality) ratings (0 = no suicidality; 1–2 = mild/moderate suicidality; 3–4 = severe suicidality). Chi-squared tests, analyses of covariance, and Spearman correlation analyses were applied for the data analyses. Results: The prevalence rate of suicidality in major depressive disorder amounted to 46.67% (Hamilton Rating Scale for Depression item 3 score ≥1). 53.33% were allocated into the no, 38.44% into the mild/moderate, and 8.23% into the severe suicidality patient group. Due to the stratification of our major depressive disorder patient sample according to different levels of suicidality, we identified some socio-demographic, psychosocial, and clinical variables differentiating from the patient group without suicidality already in presence of mild/moderate suicidality (depressive symptom severity, treatment resistance, psychotic features, add-on medications in general), whereas others separated only when severe suicidality was manifest (inpatient treatment, augmentation with antipsychotics and benzodiazepines, melancholic features, somatic comorbidities). Conclusions: As even mild/moderate suicidality is associated with a failure of achieving treatment response, adequate recognition of this condition should be ensured in the clinical practice. |