par Stryckmans, Pierre 
;Debusscher, Louise ;Ronge, Elisabeth ;Manaster, Joseph ;Delalieux, G.
Référence Leukemia research, 1, 2-3, page (133-139)
Publication Publié, 1977
;Debusscher, Louise ;Ronge, Elisabeth ;Manaster, Joseph ;Delalieux, G.Référence Leukemia research, 1, 2-3, page (133-139)
Publication Publié, 1977
Article révisé par les pairs
| Résumé : | The number of blood leukemic blast cells in human leukemias at the time of diagnosis has a prognostic value in terms of survival. In 5 patients studied, the blood blast count was found to be positively correlated with the number of blasts in the bone marrow and other proliferating and blast releasing sites. The present work indicates also that marrow blood cells in S, G2 and M are not released into the blood. This was shown by blocking them in these phases of the cell cycle by different antileukemic agents. The larger size of the blasts in S, G2 and mitosis as compared to the size in G1 could partly explain the inability of S, G2 and mitotic cells to egress from the marrow. Leukapheresis in one patient caused rapid recruitment of blasts in the blood. This recruitment was not due to release of blasts from the marrow. © 1977. |
