Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

Gonzalez-Duque, Sergio; Azoury, Marie Eliane; Colli, Maikel Luis; Afonso, Georgia; Turatsinze, Jean Valéry; Nigi, Laura; Lalanne, Ana Ines; Sebastiani, Guido; Carré, Alexia; Pinto, Sheena; Culina, Slobodan; Corcos, Noémie; Bugliani, Marco; Marchetti, Piero; Armanet, Mathieu; Diedisheim, Marc; Kyewski, Bruno; Steinmetz, Lars L.M.; Buus, Søren; You, Sylvaine; Dubois-Laforgue, Daniele; Larger, Etienne; Beressi, Jean Paul; Bruno, Graziella; Dotta, Francesco; Scharfmann, Raphaël; Eizirik, Decio L.; Verdier, Yann; Vinh, Joëlle; Mallone, Roberto

doi:doi/10.1016/j.cmet.2018.07.007

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Article révisé par les pairs

Résumé :

Mallone et al. use peptidomics and transcriptomics to identify the epitopes presented by β cells that trigger type 1 diabetes (T1D) autoimmunity. Multiple pathways, including conventional processing and mRNA and peptide splicing, are involved in epitope generation and presentation; these epitopes are selectively recognized by pancreas-infiltrating CD8+ T lymphocytes in T1D patients.

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