Initiation of anti-retroviral therapy before pregnancy reduces the risk of infection-related hospitalization in HIV-exposed uninfected infants born in a high-income country.

Goetghebuer, Tessa; Smolen, Kinga; Adler, Catherine; Das, Jishnu; McBride, Trevor; Smits, Gaby; Lecomte, Sandra; Haelterman, Edwige; Barlow, Patricia; Piedra, Pedro A; van der Klis, Fiona; Kollmann, Tobias R; Lauffenburger, Douglas A; Alter, Galit; Levy, Jack; Marchant, Arnaud

doi:doi/10.1093/cid/ciy673

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Article révisé par les pairs

Résumé :

Epidemiological studies conducted in low and high-income countries showed that infants exposed to maternal HIV but not infected themselves by the virus have a high risk of severe infections. Immune alterations during fetal life have been proposed as a possible mechanism.

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