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The house dust mite allergen Der p 5 binds lipid ligands and stimulates airway epithelial cells through a TLR2-dependent pathway.

par Pulsawat, Pinya;Soongrung, Tewarit;Satitsuksanoa, Pattraporn;Le Mignon, Maxime;Khemili, Souad ;Gilis, Dimitri ;Nony, Emmanuel;Kennedy, Malcolm W;Jacquet, Alain
Référence Clinical and experimental allergy, 49, page (378-390)
Publication Publié, 2019-11-01

Article révisé par les pairs

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Résumé :

Protein crystallographic studies suggest that the house dust mite (HDM) allergen Der p 5 potentially interacts with hydrophobic ligands. Der p 5, in association with its ligand(s), might therefore trigger innate immune signalling pathways in the airway epithelium and influence the initiation of the HDM-allergic response.