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Can GABA turn pancreatic alpha-cells into beta-cells?

par Eizirik, Decio L. ;Gurzov, Esteban Nicolas
Référence Nature reviews. Endocrinology, 14, 11, page (629-630)
Publication Publié, 2018-11-01

Article révisé par les pairs

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Résumé :

The neurotransmitter GABA has been shown to induce the transdifferentiation of α-cells into β-cells, restoring normoglycaemia in a mouse model of diabetes mellitus. A recent paper by Amanda Ackermann and colleagues, however, failed to reproduce these findings. Here, we discuss the discrepant findings and propose a systematic approach to solve the controversy.