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Synthesis of Diketones, Ketoesters, and Tetraketones by Electrochemical Oxidative Decarboxylation of Malonic Acid Derivatives: Application to the Synthesis of cis-Jasmone

par Ma, Xiaofeng;Dewez, Damien ;Du, Le;Luo, Xiya;Markó, István I.E.;Lam, Kevin
Référence Journal of organic chemistry, 83, 19, page (12044-12055)
Publication Publié, 2018-10-01

Article révisé par les pairs

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Résumé :

Disubstituted malonic acid derivatives are smoothly converted into diketones and ketoesters in good to excellent yield (68% to 91%) under electrochemical conditions. The scope can be extended to transform trisubstituted bis-malonic acids into tetraketones in 77% to 86% yield. The new method was applied to the total synthesis of cis-jasmone.