par Virreira Bermudez, Myrna 
;Jin, Ling ;Djerbib, Sami ;De Deken, Xavier ;Miot, Françoise ;Massart, Claude ;Svoboda, Michal ;Van Sande, Jacqueline ;Beauwens, Renaud ;Dumont, Jacques Emile ;Boom, Alain
Référence Thyroid
Publication Publié, 2019-01-01
;Jin, Ling ;Djerbib, Sami ;De Deken, Xavier ;Miot, Françoise ;Massart, Claude ;Svoboda, Michal ;Van Sande, Jacqueline ;Beauwens, Renaud ;Dumont, Jacques Emile ;Boom, Alain Référence Thyroid
Publication Publié, 2019-01-01
Article révisé par les pairs
| Résumé : | The intrafollicular space of thyroid follicles is the storage compartment for thyroid hormones. Its pH has been established at around 7.6 at least after thyrotropin (TSH) stimulation. This alkaline intrafollicular pH is thought to be critical for iodide coupling to thyroglobulin and internalization of iodinated thyroglobulin. At least in mice, this alkalinization requires the expression of pendrin (Slc26a4) within the apical membrane, and a lack of pendrin results in acidic follicular lumen pH. Yet, the mechanism importing HCO3- into the cytoplasm is unknown. This study investigated whether the rather ubiquitous sodium bicarbonate cotransporter NBCe1 (SLC4A4) might play this role. It also examined which variant was expressed and where it was localized in both rat and human thyroid tissue. Lastly, the dependence of its expression on TSH was studied. |
