par Lavendomme, Roy 
Référence Young Belgium Magnetic Resonance Scientist (13th: 2014: Spa, Belgium)
Publication Non publié, 2014
Référence Young Belgium Magnetic Resonance Scientist (13th: 2014: Spa, Belgium)
Publication Non publié, 2014
Communication à un colloque
| Résumé : | Calixarenes are polyphenolic macrocycles used in host-guest chemistry for the design of molecular receptors. We are currently developing a new strategy for the tailored, and highly selective, functionalization of such compounds.Calixarenes exhibit high conformational flexibility originating from the rotation of the phenolic units through the macrocycle annulus. Due to the coexistence of several atropisomers or conformers, and/or as a consequence of inherent chirality, the characterization of calixarene derivatives by solution-state NMR spectroscopy may look like a nightmare at first sight. Indeed, depending on the nature and number of substituent groups, as well as on the experimental conditions, calixarene derivatives may yield numerous and/or broadened 1H NMR signals, leading to poorly resolved overall spectra.These issues will be overviewed, hints for obtaining suitable NMR spectra will be given, the strategy used for signal assignment will be presented and additional topics related to the characterization of some calixarene derivatives that were synthesized in our laboratory will be illustrated. |
