par Galand, Paul
Référence Growth Regulation and Carcinogenesis: Volume I, CRC Press, page (121-130)
Publication Publié, 2018-01
Partie d'ouvrage collectif
Résumé : The concept has now gained wide acceptance that carcinogenesis is a multistep process. 1-J After the two operationally defined stages termed “initiation” and “promotion”, more steps seem required before full-fledged malignancy arises, corresponding to transplantable tumors. The term “progression” is used to cover the ill-defined scale of changes in cellular properties which induces what we might call the “minimal fully malignant phenotype”, implying “unlimited” proliferative potential, and the capability to grow invasively and to metastasize in ectopic sites.