par Tran Van Nhieu, Guy;Dupont, Geneviève 
;Combettes, Laurent
Référence Biochimica et biophysica acta. Molecular cell research, 1865, 11, page (1838-1845)
Publication Publié, 2018-11
;Combettes, LaurentRéférence Biochimica et biophysica acta. Molecular cell research, 1865, 11, page (1838-1845)
Publication Publié, 2018-11
Article révisé par les pairs
| Résumé : | Recent reports have highlighted the pivotal role of Ca2+ during host cell infection by bacterial pathogens. Here, we review how bacterial pore-forming toxins (PFTs) trigger global Ca2+ signals to regulate cell adhesion-, inflammatory- or death processes. We comment recent reports describing the role of bacterial effectors injected by a type III secretion system (T3SS) as well as host cell players in the formation of Ca2+ microdomains during Shigella invasion and Chlamydia extrusion of host cells. We discuss how modeling and comparison between bacterial-induced and physiological Ca2+ microdomains provides insight into the critical parameters shaping the duration of local Ca2+ responses. |
