par Preyat, Nicolas ;Leo, Oberdan
Référence Molecular and Cellular Oncology, 3, 1, e1062591
Publication Publié, 2016-01
Article révisé par les pairs
Résumé : The mechanisms regulating the choice of cell demise remain largely unknown. NAD+, a key metabolite with well-known roles in cell metabolism, has been shown to counteract apoptosis while promoting necroptosis, a form of proinflammatory cell death. This observation identifies NAD+ availability as an important parameter with contrasting roles in the regulation of distinct regulated cell death programs.