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The influence of heparin on the bactericidal activity rate of gentamicin

par Yourassowsky, Eugène ;Debroe, Marc;Vanderlinden, M P;Monsieur, Rita
Référence PATH.BIOL., 22, 5, page (389-391)
Publication Publié, 1974

Article révisé par les pairs

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Résumé :

Several authors have demonstrated the interaction between gentamicin and heparin and their formation of a high molecular weight complex. The dosages of this antibiotic are not exact, the diffusion in agar of the heparin gentamicin complex being slower than that of gentamicin alone. Therapeutically, heparin and gentamicin are sometimes simultaneously used (hemodialysis, intravascular coagulation syndrome) and a loss of antibacterial activity of gentamicin, is, in this case, possible. The object of this study is the influence of heparin on the bactericidal activity of gentamicin. These procedures, undertaken in a liquid medium, set aside the influence of the molecular weight of the complex, a determining factor of 'antagonism' shown by the methods of agar diffusion. In order to approach the in vivo situation, the bactericidal study was performed in serum of a patient treated with high gentamicin dosage. It was found that in the presence of heparin, the bactericidal action rate of the serum of the patients treated with gentamicin was slowed down.