par Alvelos, Maria Inês;Juan-Mateu, Jonàs;Colli, Maikel Luis 
;Turatsinze, Jean Valéry ;Eizirik, Decio L.
Référence Diabetes, obesity and metabolism, 20 Suppl 2, page (77-87)
Publication Publié, 2018
;Turatsinze, Jean Valéry ;Eizirik, Decio L. Référence Diabetes, obesity and metabolism, 20 Suppl 2, page (77-87)
Publication Publié, 2018
Article révisé par les pairs
| Résumé : | Pancreatic β-cell dysfunction and death are determinant events in type 1 diabetes (T1D), but the molecular mechanisms behind β-cell fate remain poorly understood. Alternative splicing is a post-translational mechanism by which a single gene generates different mRNA and protein isoforms, expanding the transcriptome complexity and enhancing protein diversity. Neuron-specific and certain serine/arginine-rich RNA binding proteins (RBP) are enriched in β-cells, playing crucial roles in the regulation of insulin secretion and β-cell survival. Moreover, alternative exon networks, regulated by inflammation or diabetes susceptibility genes, control key pathways and processes for the correct function and survival of β-cells. The challenge ahead of us is to understand the precise role of alternative splicing regulators and splice variants on β-cell function, dysfunction and death and develop tools to modulate it. |
