• Citer

Broadly Applicable Ytterbium-Catalyzed Esterification, Hydrolysis and Amidation of Imides

par Guissart, Céline ;Barros, Andre;Rosa Barata, Luis;Evano, Gwilherm
Référence Organic letters, 20, page (5098-5102)
Publication Publié, 2018

Article révisé par les pairs

• Accès en ligne
• Détails
• Contenu
• Statistiques

Résumé :

An efficient, broadly applicable, operationally simple and divergent process for the transformation of imides into arange of carboxylic acid derivatives under mild conditions is reported. By simply using catalytic amounts of ytterbium(III) triflate asa Lewis acid promoter in the presence of alcohols, water, amines or N,O-dimethylhydroxylamine, a broad range of imides aresmoothly and readily converted to the corresponding esters, carboxylic acids, amides and Weinreb amides in good yields. This methodnotably enables an easy cleavage of oxazolidinone-based auxiliaries.