The light chain IgLV3-21 defines a new poor prognostic subgroup in Chronic Lymphocytic Leukemia: results of a multicenter study.

Stamatopoulos, Basile; Smith, Thomas Bates; Crompot, Emerence; Pieters, Karlien; Clifford, Ruth; Mraz, Marek; Robbe, Pauline; Burns, Adam; Timbs, Adele; Bruce, D.W; Hillmen, Peter; Meuleman, Nathalie; Mineur, Philippe; Firescu, R; Maerevoet, Marie; De Wilde, Virginie; Efira, André; Philippé, Jan; Verhasselt, Bruno; Offner, Firtz; Sims, David; Heger, Andreas; Dreau, Hélène; Schuh, Anna

doi:doi/10.1158/1078-0432.CCR-18-0133

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Résumé :

Unmutated (UM) immunoglobulin heavy chain variable region (IgHV) status or IgHV3-21 gene usage is associated with poor prognosis in chronic lymphocytic leukemia (CLL) patients. Interestingly, IgHV3-21 is often co-expressed with light chain IgLV3-21, which is potentially able to trigger cell-autonomous BCR-mediated signaling. However, this light chain has never been characterized independently of the heavy chain IgHV3-21.

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