Association of T-Cell Receptor Repertoire Use With Response to Combined Trastuzumab-Lapatinib Treatment of HER2-Positive Breast Cancer: Secondary Analysis of the NeoALTTO Randomized Clinical Trial.

Powles, Ryan L; Redmond, David; Sotiriou, Christos; Loi, Sherene; Fumagalli, Debora; Nuciforo, Paolo; Harbeck, Nadia; de Azambuja, Evandro; Sarp, Severine; Di Cosimo, Serena; Huober, Jens; Baselga, José; Piccart-Gebhart, Martine; Elemento, Olivier; Pusztai, Lajos; Hatzis, Christos

doi:doi/10.1001/jamaoncol.2018.1564

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Article révisé par les pairs

Résumé :

Dual anti-HER2 blockade increased the rate of pathologic complete response (pCR) in the Neoadjuvant Lapatinib and/or Trastuzumab Treatment Optimisation (NeoALTTO) trial, and high immune gene expression was associated with pCR in all treatment arms. So far, no marker has been identified that is specifically associated with the benefit from dual HER2 blockade.

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