• Citer

Low and high body mass index in hidradenitis suppurativa patients—different subtypes?

par Theut Riis, Peter;Saunte, Ditte Marie Lindhardt D.M.;Benhadou, Farida ;Del Marmol, Véronique ;Guillem, Philippe;El-Domyati, Moetaz;Abdel-Wahab, Hossam;Antoniou, Christina;Dessinioti, Clio;Gürer, Mehmet Ali;Beksaç, B.;Szepietowski, Jacek J.C.;Matusiak, Łukasz L.;Emtestam, Lennart;Lapins, Jan;Riad, Hassan;Doss, Néjib;Massa, A.F.;Hamzavi, Iltefat;Nicholson, Cynthia;Dolenc-Voljc, Mateja;Kim, K.H.;Ohn, Junghun;Zouboulis, Christos C.C.;Karagiannidis, Ioannis;Mokos, Zrinka Bukvić;Durinec, Paola;Jemec, Gregor
Référence JEADV. Journal of the European Academy of Dermatology and Venereology, 32, 2, page (307-312)
Publication Publié, 2018-02

Article révisé par les pairs

• Détails
• Contenu

Résumé :

Introduction: Overweight is a well-established risk factor for hidradenitis suppurativa (HS). In this cross-sectional study, we compare HS patients with a high body mass index (BMI) with HS patients with a low BMI to investigate differences in disease characteristics. Materials and method: Patients were recruited from 17 dermatological centres from four continents. A total of 246 patients with a BMI below 25 were compared to 205 patients with a BMI of above 35. Results: Patients with a high BMI suffered more severe disease (Hurley, physician global assessment, number of areas affected and patient-reported severity (PRS), P < 0.001 for all). There was no difference in smoking (P = 0.783) nor in family history (P = 0.088). In both low and high BMI patients, early onset of HS was a predictor of positive family history (P < 0.001, for each). For low BMI patients, an increase in BMI significantly increased PRS (P < 0.001). For patients with a high BMI, number of pack-years significantly increased PRS (P = 0.001). Cluster analysis of eruption patterns was location specific for low BMI patients but severity specific for high BMI patients. Discussion: Patients with a low and high BMI could represent two clinically different subtypes. We suggest a non-linear relationship between BMI and impact of HS. As patients go from a low BMI patient to a high BMI patient (or from high to low), eruption patterns and risk factors may change.