Résumé : The impact of multi-dimensional effects on the auto-ignition of the iso-octane was studied through comparison of 0-D and RANS simulations of the Argonne Rapid Compression Machines (RCM). A detailed kinetic mechanism was applied providing an accurate description of both the physical and chemical phenomena in an RCM context for a complex fuel. The effect of the inhomogeneities on the ignition delay was globally marginal except for the lowest temperature condition considered where the diffusive transport of intermediate species and radicals plays a crucial role. No significant effect of mass transfer to the crevices on the auto-ignition delay was noted under the test conditions. The sensitivity of the results to the turbulence level showed that turbulence may only exert a minimal effect on the auto-ignition delay.