par Bamford, Alasdair;Turkova, Anna;Lyall, Hermione;Foster, Caroline C.J.;Klein, Nigel;Bastiaans, Diane Et;Burger, David;Bernadi, S.;Butler, Karina K.M.;Chiappini, Elena;Clayden, Polly;Della Negra, Marinella;Giacomet, Vania;Giaquinto, Carlo;Gibb, Diana;Galli, Luisa;Hainaut, Marc
;Koros, M.;Marques, Laura L.C.;Nastouli, Eleni;Niehues, Tim;Noguera-Julian, Antoni;Rojo, Pablo;Rudin, Christoph;Scherpbier, Henriëtte J J H.;Tudor-Williams, Gareth;Welch, Steven S.B.
Référence HIV medicine, 19, 1, page (e1-e42)
Publication Publié, 2018-01

Référence HIV medicine, 19, 1, page (e1-e42)
Publication Publié, 2018-01
Article révisé par les pairs
Résumé : | The 2015 Paediatric European Network for Treatment of AIDS (PENTA) guidelines provide practical recommendations on the management of HIV-1 infection in children in Europe and are an update to those published in 2009. Aims of treatment have progressed significantly over the last decade, moving far beyond limitation of short-term morbidity and mortality to optimizing health status for adult life and minimizing the impact of chronic HIV infection on immune system development and health in general. Additionally, there is a greater need for increased awareness and minimization of long-term drug toxicity. The main updates to the previous guidelines include: an increase in the number of indications for antiretroviral therapy (ART) at all ages (higher CD4 thresholds for consideration of ART initiation and additional clinical indications), revised guidance on first- and second-line ART recommendations, including more recently available drug classes, expanded guidance on management of coinfections (including tuberculosis, hepatitis B and hepatitis C) and additional emphasis on the needs of adolescents as they approach transition to adult services. There is a new section on the current ART ‘pipeline’ of drug development, a comprehensive summary table of currently recommended ART with dosing recommendations. Differences between PENTA and current US and World Health Organization guidelines are highlighted and explained. |