par Reuse, Joannes 
Référence BULL.ACAD.ROY.MED.BELG., 13, 4, page (331-353)
Publication Publié, 1973
Référence BULL.ACAD.ROY.MED.BELG., 13, 4, page (331-353)
Publication Publié, 1973
Article révisé par les pairs
| Résumé : | An analysis of the medical and pharmacological literature on the gastrointestinal action of metoclopramide is presented. A pharmacological analysis of the effects of metoclopramide on the guinea pig isolated ileum is presented. Metoclopramide (3-60 μg/ml) produces either a sustained tonic response or a short tonic contraction followed by phasic movements. Concentrations above 100 μg/ml induce a relaxation of the ileum. The response to stimulating concentrations of metoclopramide is cholinergic (partial and reversible inhibition by atropine or hyoscine) of indirect neuronal origin (partial and reversible inhibition by tetrodotoxine, morphine and procaine) but is not affected by ganglionic blocking concentrations of hexamethonium. Methysergide, a potent 5 hydroxytryptamine antagonist, is also partially and reversibly inhibiting stimulating responses to metoclopramide. After addition of both hyoscine (or tetrodotoxine) and methysergide, the stimulating effect of metoclopramide is abolished or reversed to a relaxation. Metoclopramide increases the response of the ileum to acetylcholine, nicotine and transmural stimulation, but inhibits the effect of histamine and serotonine. The indirect mechanism of the stimulatory effect of metoclopramide on the studied preparation could be understood by postulating a liberation of 5 hydroxytryptamine from stores in the guinea pig ileum and by its demonstrated sensitizing effect on acetylcholine receptors. |
