par L'Hermite, Marc 
;Degueldre, Michel ;Caufriez, Anne ;Delvoye, Pierre ;Robyn, Claude
Référence Pathologie et biologie, 23, 10, page (769-778)
Publication Publié, 1975
;Degueldre, Michel ;Caufriez, Anne ;Delvoye, Pierre ;Robyn, Claude Référence Pathologie et biologie, 23, 10, page (769-778)
Publication Publié, 1975
Article révisé par les pairs
| Résumé : | Human prolactin blood levels were determined by radioimmunoassay in basal condition and in response to various inhibiting and/or stimulating agents (levodopa, water overload, insulinic hypoglycaemia, synthetic TRH, sulpiride) in cases of disturbed hypothalamo pituitary axis (failure to lactate, prolactin secreting pituitary adenomas, acromegaly, other pituitary tumours, clinical panhypopituitarism). A blunted prolactin response to suckling was evidenced in 2 post partum women who were unable to breast feed. Hyperprolactinaemia whether related to the existence of a prolactin producing adenoma or not, was associated with the disappearance of the normal circadian pattern of prolactin secretion and with a blunted relative response to TRH; the latter phenomenon also occurred in acromegaly regardless of the basal prolactinaemia and during the last trimester of pregnancy. Water overload was unsuccessful in suppressing prolactin during the last trimester of pregnancy while the acute administration of levodopa was quite effective in about half of the patients with pituitary tumour. Therefore none of the dynamic tests presently studied allowed us to attribute hyperprolactinaemia to a pituitary tumour rather than to a functional disturbance. On the other hand, stimulation tests can help to locate the level of a defect in cases of hypopituitarism. |
