Titre:
  • Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules.
Auteur:Christensen, Erik I; Devuyst, Olivier; Dom, Geneviève; Nielsen, Rikke; Van der Smissen, Patrick; Verroust, Pierre; Leruth, Michèle; Guggino, William B; Courtoy, Pierre Joseph
Informations sur la publication:Proceedings of the National Academy of Sciences of the United States of America, 100, 14, page (8472-8477)
Statut de publication:Publié, 2003-07
Sujet CREF:Sciences bio-médicales et agricoles
MeSH keywords:Absorption
Animals
Blood Proteins -- metabolism
Cell Polarity
Chloride Channels -- deficiency -- genetics -- physiology
Endocytosis
Endosomes -- metabolism
Fanconi Syndrome -- metabolism
Hydrogen-Ion Concentration
Immunohistochemistry
Ion Transport
Kidney Tubules, Proximal -- metabolism -- ultrastructure
Ligands
Low Density Lipoprotein Receptor-Related Protein-2 -- genetics -- metabolism
Male
Mice
Mice, Knockout
Microvilli -- metabolism
Protein Transport
RNA, Messenger -- biosynthesis
Receptors, Cell Surface -- genetics -- metabolism
rab GTP-Binding Proteins -- metabolism
rab5 GTP-Binding Proteins -- metabolism
Langue:Anglais
Identificateurs:urn:issn:0027-8424
info:doi/10.1073/pnas.1432873100
info:pii/1432873100
info:pmid/12815097
PMC166253