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Cephalosporin antibiotics at carbon paste and modified carbon paste electrodes in both aqueous and biological media

par Kauffmann, Jean-Michel ;El-Maali, N. A.;Ghandour, Mahmoud A.
Référence Bioelectrochemistry and Bioenergetics, 38, 1, page (91-97)
Publication Publié, 1995

Article révisé par les pairs

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Résumé :

A sensitive voltammetric method has been developed for the oxidation and determination of the cephalosporin antibiotics Cefatrexyl, Velosef, Claforan, Cefobid and Rocephin at both carbon paste and modified fatty acid carbon paste electrodes. The electroanalytical technique used was direct current stripping voltammetry. The adsorptive stripping response was evaluated as a function of preconcentration time, preconcentration potential, modifier percentage and other variables. The effect of the interfering materials such as ascorbic acid, uric acid and some metal ions, i.e. Cu(II) and Fe(III), has also been taken into consideration. A detection limit down to 10-8 M has easily been achieved. Application of the method to biological samples (e.g. urine and serum) has been assessed. © 1995.