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The radiosensitising effect of gemcitabine and its main metabolite dFdU under low oxygen conditions is in vitro not dependent on functional HIF-1 protein.

par Wouters, An;Pauwels, Bea;Burrows, Natalie;Baay, Marc;Deschoolmeester, Vanessa;Vu, Trung Nghia;Laukens, Kris;Meijnders, Paul;Van Gestel, Dirk ;Williams, Kaye J;Van den Weyngaert, Danielle;Vermorken, Jan B;Pauwels, Patrick;Peeters, Marc;Lardon, Filip
Référence BMC cancer, 14, page (594)
Publication Publié, 2014-08

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Titre:	The radiosensitising effect of gemcitabine and its main metabolite dFdU under low oxygen conditions is in vitro not dependent on functional HIF-1 protein.
Auteur:	Wouters, An; Pauwels, Bea; Burrows, Natalie; Baay, Marc; Deschoolmeester, Vanessa; Vu, Trung Nghia; Laukens, Kris; Meijnders, Paul; Van Gestel, Dirk; Williams, Kaye J; Van den Weyngaert, Danielle; Vermorken, Jan B; Pauwels, Patrick; Peeters, Marc; Lardon, Filip
Informations sur la publication:	BMC cancer, 14, page (594)
Statut de publication:	Publié, 2014-08
Sujet CREF:	Sciences bio-médicales et agricoles
	Cancérologie
MeSH keywords:	Breast Neoplasms
	Cell Cycle -- drug effects -- radiation effects
	Cell Hypoxia -- drug effects -- radiation effects
	Cell Line, Tumor
	Deoxycytidine -- analogs & derivatives -- pharmacology
	Deoxyuridine -- analogs & derivatives -- pharmacology
	Female
	Humans
	Hypoxia-Inducible Factor 1 -- metabolism
	Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism
	In Vitro Techniques
	Radiation-Sensitizing Agents -- pharmacology
Langue:	Anglais
Identificateurs:	urn:issn:1471-2407
	info:doi/10.1186/1471-2407-14-594
	info:pii/1471-2407-14-594
	info:pmid/25128202
	PMC4152599