par Pucci, Fabrizio 
;Rooman, Marianne
Référence Physical Review E, 98, 1, 012137
Publication Publié, 2018-07
;Rooman, Marianne Référence Physical Review E, 98, 1, 012137
Publication Publié, 2018-07
Article révisé par les pairs
| Résumé : | Understanding under which conditions the increase of systems complexity is evolutionarily advantageous, and how this trend is related to the modulation of the intrinsic noise, are fascinating issues of utmost importance for synthetic and systems biology. To get insights into these matters, we analyzed a series of chemical reaction networks with different topologies and complexity, described by mass-action kinetics. We showed, analytically and numerically, that the global level of fluctuations at the steady state, measured by the sum over all species of the Fano factors of the number of molecules, is directly related to the network's deficiency. For zero-deficiency systems, this sum is constant and equal to the rank of the network. For higher deficiencies, additional terms appear in the Fano factor sum, which are proportional to the net reaction fluxes between the molecular complexes. We showed that the system's global intrinsic noise is reduced when all fluxes flow from lower to higher degree oligomers, or equivalently, towards the species of higher complexity, whereas it is amplified when the fluxes are directed towards lower complexity species. |
