par Darcis, Gilles 
;Van Driessche, Benoît ;Bouchat, Sophie ;Kirchhoff, Frank;Van Lint, Carine
Référence Current topics in microbiology and immunology
Publication Publié, 2017-10
;Van Driessche, Benoît ;Bouchat, Sophie ;Kirchhoff, Frank;Van Lint, Carine Référence Current topics in microbiology and immunology
Publication Publié, 2017-10
Article révisé par les pairs
| Résumé : | The HIV latent reservoirs are considered as the main hurdle to viral eradication. Numerous mechanisms lead to the establishment of HIV latency and act at the transcriptional and post-transcriptional levels. A better understanding of latency is needed in order to ultimately achieve a cure for HIV. The mechanisms underlying latency vary between patients, tissues, anatomical compartments, and cell types. From this point of view, simian immunodeficiency virus (SIV) infection and the use of nonhuman primate (NHP) models that recapitulate many aspects of HIV-associated latency establishment and disease progression are essential tools since they allow extensive tissue sampling as well as a control of infection parameters (virus type, dose, route, and time). |
