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Cabozantinib targets bone microenvironment modulating human osteoclast and osteoblast functions.

par Fioramonti, Marco ;Santini, Daniele;Iuliani, Michele;Ribelli, Giulia;Manca, Paolo;Papapietro, Nicola;Spiezia, Filippo;Vincenzi, Bruno;Denaro, Vincenzo;Russo, Antonio;Tonini, Giuseppe;Pantano, Francesco
Référence Oncotarget, 8, 12, page (20113-20121)
Publication Publié, 2017-03

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Titre:	Cabozantinib targets bone microenvironment modulating human osteoclast and osteoblast functions.
Auteur:	Fioramonti, Marco; Santini, Daniele; Iuliani, Michele; Ribelli, Giulia; Manca, Paolo; Papapietro, Nicola; Spiezia, Filippo; Vincenzi, Bruno; Denaro, Vincenzo; Russo, Antonio; Tonini, Giuseppe; Pantano, Francesco
Informations sur la publication:	Oncotarget, 8, 12, page (20113-20121)
Statut de publication:	Publié, 2017-03
Sujet CREF:	Sciences bio-médicales et agricoles
Mots-clés:	bone microenvironment
	cabozantinib
	human primary cells
	osteoprotegerin (OPG)
	receptor activator of nuclear factor-kb ligand (RANKL)
MeSH keywords:	Anilides -- pharmacology
	Apoptosis
	Blotting, Western
	Bone Resorption -- drug therapy -- metabolism -- pathology
	Cell Differentiation -- drug effects
	Cell Proliferation
	Cells, Cultured
	Humans
	Immunoenzyme Techniques
	Osteoblasts -- cytology -- drug effects -- physiology
	Osteoclasts -- cytology -- drug effects -- physiology
	Osteogenesis -- drug effects -- physiology
	Osteoprotegerin -- genetics -- metabolism
	Proto-Oncogene Proteins c-met -- genetics -- metabolism
	Pyridines -- pharmacology
	RANK Ligand -- genetics -- metabolism
	RNA, Messenger -- genetics
	Real-Time Polymerase Chain Reaction
	Receptor Activator of Nuclear Factor-kappa B -- genetics -- metabolism
	Reverse Transcriptase Polymerase Chain Reaction
Langue:	Anglais
Identificateurs:	urn:issn:1949-2553
	info:doi/10.18632/oncotarget.15390
	info:pii/15390
	info:pmid/28223547
	PMC5386748