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Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions.

par Picco, Gabriele;Petti, Consalvo;Centonze, Alessia ;Torchiaro, Erica;Crisafulli, Giovanni;Novara, Luca;Acquaviva, Andrea;Bardelli, Alberto;Medico, Enzo
Référence EMBO molecular medicine, 9, 3, page (293-303)
Publication Publié, 2017-03

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Titre:	Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions.
Auteur:	Picco, Gabriele; Petti, Consalvo; Centonze, Alessia; Torchiaro, Erica; Crisafulli, Giovanni; Novara, Luca; Acquaviva, Andrea; Bardelli, Alberto; Medico, Enzo
Informations sur la publication:	EMBO molecular medicine, 9, 3, page (293-303)
Statut de publication:	Publié, 2017-03
Sujet CREF:	Sciences bio-médicales et agricoles
Mots-clés:	R‐spondin
	WNT pathway
	colorectal cancer
	gene fusion
	targeted therapy
MeSH keywords:	Axin Protein -- deficiency
	Cell Line, Tumor
	Cell Proliferation
	Colorectal Neoplasms -- pathology
	Drug Resistance
	Enzyme Inhibitors -- pharmacology
	Gene Fusion
	Humans
	Pyrazines -- pharmacology
	Pyridines -- pharmacology
	Thrombospondins -- genetics
	Wnt Proteins -- metabolism
	Wnt Signaling Pathway
Langue:	Anglais
Identificateurs:	urn:issn:1757-4676
	info:doi/10.15252/emmm.201606773
	info:pii/emmm.201606773
	info:pmid/28100566
	PMC5331210