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Unravelling triple-negative breast cancer molecular heterogeneity using an integrative multiomic analysis.

par Bareche, Yacine ;Venet, David ;Ignatiadis, Michail ;Aftimos, Philippe ;Piccart-Gebhart, Martine ;Rothé, Françoise ;Sotiriou, Christos
Référence Annals of oncology
Publication Publié, 2018-01

Article révisé par les pairs

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Résumé :

Recent efforts of genome-wide gene expression profiling analyses have improved our understanding of the biological complexity and diversity of triple negative breast cancers (TNBCs) reporting, at least 6 different molecular subtypes of TNBC namely Basal-like 1 (BL1), basal-like 2 (BL2), immunomodulatory (IM), mesenchymal (M), mesenchymal stem-like (MSL) and luminal androgen receptor (LAR). However, little is known regarding the potential driving molecular events within each subtype, their difference in survival and response to therapy. Further insight into the underlying genomic alterations is therefore needed.