Cardiac biomarkers for early detection and prediction of trastuzumab and/or lapatinib-induced cardiotoxicity in patients with HER2-positive early-stage breast cancer: a NeoALTTO sub-study (BIG 1-06).

Ponde, Noam; Bradbury, Ian; Lambertini, Matteo; Ewer, Michael S; Campbell, Christine; Ameels, Helene; Zardavas, Dimitrios; Di Cosimo, Serena; Baselga, José; Huober, Jens; Izquierdo, Miguel; Fumagalli, Debora; Bozovic-Spasojevic, Ivana; Maetens, Marion M.; Harbeck, Nadia; Pusztai, Lajos; Berghorn, Michael; Im, Young Hyuck; Borrego, Manuel Ruiz; Chen, Dar-Ren; Rodeheffer, Richard; Piccart-Gebhart, Martine; Suter, Thomas; de Azambuja, Evandro

doi:doi/10.1007/s10549-017-4628-3

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Article révisé par les pairs

Résumé :

Biomarkers of cardiac damages, such as troponin T (TnT) and the amino-terminal fragment of brain natriuretic peptide (NT-proBNP), may be useful as early predictors of cardiac dysfunction. The role of these biomarkers in patients receiving lapatinib and/or trastuzumab before anthracyclines is unknown. This study explores TnT and NT-proBNP as predictors of early cardiac toxicity in neoadjuvant breast cancer patients.

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