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CpG island methylator phenotype-positive tumors in the absence of MLH1 methylation constitute a distinct subset of duodenal adenocarcinomas and are associated with poor prognosis.

par Fu, Tao;Pappou, Emmanouil E.P.;Guzzetta, Angela AA;Jeschke, Jana ;Kwak, Ruby;Dave, Pujan;Hooker, Craig M;Morgan, Richard;Baylin, Stephen B;Iacobuzio-Donahue, Christine A;Wolfgang, Christopher L;Ahuja, Nita
Référence Clinical cancer research, 18, 17, page (4743-4752)
Publication Publié, 2012-09

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Titre:	CpG island methylator phenotype-positive tumors in the absence of MLH1 methylation constitute a distinct subset of duodenal adenocarcinomas and are associated with poor prognosis.
Auteur:	Fu, Tao; Pappou, Emmanouil E.P.; Guzzetta, Angela AA; Jeschke, Jana; Kwak, Ruby; Dave, Pujan; Hooker, Craig M; Morgan, Richard; Baylin, Stephen B; Iacobuzio-Donahue, Christine A; Wolfgang, Christopher L; Ahuja, Nita
Informations sur la publication:	Clinical cancer research, 18, 17, page (4743-4752)
Statut de publication:	Publié, 2012-09
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Adaptor Proteins, Signal Transducing -- genetics -- metabolism
	Adenocarcinoma -- metabolism -- pathology
	Aged
	CpG Islands -- genetics
	DNA Methylation -- genetics
	Duodenal Neoplasms -- metabolism -- pathology
	Female
	Gene Expression Regulation, Neoplastic
	Humans
	Kaplan-Meier Estimate
	Male
	Microsatellite Instability
	Middle Aged
	MutL Protein Homolog 1
	Nuclear Proteins -- genetics -- metabolism
	Prognosis
	Proportional Hazards Models
	Proto-Oncogene Proteins -- genetics -- metabolism
	Proto-Oncogene Proteins B-raf -- genetics -- metabolism
	Proto-Oncogene Proteins p21(ras)
	ras Proteins -- genetics -- metabolism
Langue:	Anglais
Identificateurs:	urn:issn:1078-0432
	info:doi/10.1158/1078-0432.CCR-12-0707
	info:pii/1078-0432.CCR-12-0707
	info:pmid/22825585
	PMC3482463