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Severe myoglobinuric acute kidney injury in a kidney recipient: Rapid recovery after hemodialysis with the super high-flux membrane Theralite®

par Goubella, Ahmed ;Gankam Kengne, Fabrice ;Baudoux, Thomas ;Fagnoul, David ;Husson, Cécile ;Delforge, Marie-Luce ;Broeders, Emine Nilufer ;Nortier, Joëlle
Référence Clinical nephrology, 88, 6, page (359-363)
Publication Publié, 2017

Article révisé par les pairs

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Résumé :

Myoglobinuric acute kidney injury (AKI) is a severe condition requiring early therapeutic strategies. Early recognition and treatment are crucial to reduce morbidity and mortality rate. Here, we report a kidney recipient with severe rhabdomyolysis and AKI secondary to parvovirus B19 infection. Initiation of hemodialysis with the super high-flux filter Theralite® (Gambro, cut-off 45 kDa, 2.1 m2) resulted in the clearance of myoglobin from 61 to 71% after 3 hours. Elimination rates of IL-6 and β2-microglobulin were ~ 30 - 64% and 55 - 71% after 3 hours, respectively. Renal graft function rapidly recovered. The place of this effective but expensive procedure still needs to be defined and validated in high-risk patients.