par Uribe-Lewis, Santiago;Stark, Rory;Carroll, Thomas;Dunning, Mark J;Bachman, Martin;Ito, Yoko;Stojic, Lovorka;Halim, Silvia;Vowler, Sarah L;Lynch, Andy G;Delatte, Benjamin ;de Bony, Eric James ;Colin, Laurence ;Defrance, Matthieu ;Krueger, Felix;Silva, Ana Luisa;ten Hoopen, Rogier;Ibrahim, Ashraf Ek;Murrell, Adele;Fuks, François
Référence Genome biology, 16, page (69)
Publication Publié, 2015-04
Référence Genome biology, 16, page (69)
Publication Publié, 2015-04
Article révisé par les pairs
Résumé : | The discovery of cytosine hydroxymethylation (5hmC) as a mechanism that potentially controls DNA methylation changes typical of neoplasia prompted us to investigate its behaviour in colon cancer. 5hmC is globally reduced in proliferating cells such as colon tumours and the gut crypt progenitors, from which tumours can arise. |