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Cardiovascular disease (CVD) and chronic kidney disease (CKD) event rates in HIV-positive persons at high predicted CVD and CKD risk: A prospective analysis of the D:A:D observational study

par Boyd, Mark M.A.;Fontas, Eric;Phillips, Andrew N.;Bonnet, Fabrice;Reiss, Peter;Lundgren, Jens D D J.;Law, Matthew;Mocroft, Amanda;Ryom, Lene;d'Arminio Monforte, Antonella;Sabin, Caroline;El-Sadr, W.M.;Hatleberg, Camilla Ingrid;De Wit, Stéphane ;Weber, Rainer
Référence PLoS medicine, 14, 11, page (e1002424)
Publication Publié, 2017-11

Article révisé par les pairs

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Résumé :

BACKGROUND: The Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study has developed predictive risk scores for cardiovascular disease (CVD) and chronic kidney disease (CKD, defined as confirmed estimated glomerular filtration rate [eGFR] ≤ 60 ml/min/1.73 m2) events in HIV-positive people. We hypothesized that participants in D:A:D at high (>5%) predicted risk for both CVD and CKD would be at even greater risk for CVD and CKD events.